Human CD31 is an adhesion molecule expressed on platelets, endothelial cells, leukocytes and their bone marrow precursors. CD31 plays a role in homophilic adhesion and heterophilic transendothelial migration (3).

Isotype: Murine IgG1

Immunogen: Stimulated human leukocytes

Specificity: Antibody 158-2B3 reacts with domain 1 of CD31 (1).

Functional Application: Antibody 158-2B3 blocks homophilic interaction and heterophilic transendothelial migration(1). It has been used for FACS analysis of circulating Endothelial Microparticles (4).

References:

1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 362-372.

2. P.J. Newman, (1997) J Clin Invest 99: 3-10.

3. K.L. Yong, et al, (1998) Blood 91: 1196-1205.

4. AF Tramontano, L Ragolia, et al. (2010) Mediators of Inflammation 2010: 250476 doi:10.1155/2010/250476.

5. I Soaita, W Yin, D A Rubenstein (Jan 2017) Platelets http://dx.doi.org/10.1080/09537104.2016.1260703