Human CD23 is a low affinity receptor for IgE (Fc epsilon RII) found primarily on mature B cells and also on eosinophils, monocytes, dendritic cells, platelets, and a subset of thymic epithelial cells. CD23 interacts with CD21 (4).

Isotype: Murine IgG1

Immunogen: Human peripheral myeloma cells

Specificity: Antibody BU38 recognizes the CD23 molecule of 45 kd (1, 3).

Functional Application: Antibody BU38 functions as a CD23 agonist when crosslinked with anti-Mouse polyclonal antibody (5,6). Biotinylated BU38 has been used for magnetic depletion of Eosinophils (7).

References:

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 67-81.

2. D.L. Hardie, et al, (1993) Eur J Immunol 23: 997-1004.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 530-538.

4. J.Y. Bonnefoy, et al, (1995) Curr Opin Immunol 7: 355-359.

5. M.A. Chan, L.J. Rosenwasser, et al (20103) Clin Immunol 137(3): 330-336.

6. M.A. Chan, L.J. Rosenwasser, et al (2013) Am J Respir Cell Mol Biol doi:10.1165/rcmb.2013-0112OC

7. N Singh, MF Denny, et al. (2016) Dis Model Mech 9(8): 885-97. PMID: 27483354.