Human CD35 binds complement components C3b , C4b, and iC3b and is expressed on erythrocytes, B cells, monocytes, granulocytes and folicular dendritic cells and on subsets of thymocytes (3). CD35 on erythrocytes mediates clearance of immune complexes.
Isotype: Murine IgG1
Immunogen: Human monocytes
Specificity: Antibody E11 recognizes a complement receptor 1 (CD35) molecule of about 220 kd (1, 2). It is crossreactive with cynomolgus monkey CD35 (5).
References:
1. N. Hogg, et al, (1984) Eur J Immunol 14: 236-243.
2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 829-830.
3. C.C. Delibrias, et al, (1994) Eur J Immunol 24: 2784-2788.
4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 871-874.
5. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.
6. Barber, K.E., Ghebrehiwet, B., Yin, W. et al. (2017) Cel. Mol. Bioeng. 10: 124.
