Human CD34 is an unusual glycosylated membrane protein exclusively expressed on immature hematopoietic cells and on endothelial cells. CD34 may have a role in cell adhesion. CD34 has extensive utility for bone marrow transplantation (3, 4).

Isotype: Murine IgG3 kappa

Immunogen: Human KG-1a tumor cells

Specificity: Antibody 43A1 recognizes the class II epitope of the 110 kd CD34 molecule (1, 2,) which is resistant to neuraminidase and sensitive to glycoprotease (6).

References:

1. H.J. Bühring, et al, (1991) Leukemia 5: 854-860.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 840-874.

3. R.H. Collins, (1994) Stem Cells 12: 577-585.

4. T.L. Holyoake & M.J. Alcorn, (1994) Blood Reviews 8: 113-124.

5. J.P. Levesque, L.J. Bendell, et al. (2003) J Clin Invest 110: 187-196.

6. Lanza R, Sutherland DR, et al. (2001) J Biol Regulators and Homeostatic Agents 15:1-13.

7. M Vigano, de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.