Human CD21 is a receptor for complement fragments C3d, C3dg or ic3D (1, 5) and also EBV (4). CD21 is also a ligand for CD23 and plays a role in IgE synthesis (3).

Isotype: Murine IgG1

Immunogen: Human HFB-1 cell line

Specificity: Antibody BU33 recognizes the CD21 molecule of about 145 kd (1). BU33 has been shown to bind to Equine B cells, suggesting cross reactivity (7).

Functional Application: Antibody BU33 inhibits the CD21 - CD23 interaction (2, 6, 8).

References:

1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 516-523.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 535-538.

3. J.Y. Bonnefoy, et al, (1995) Intl Archiv Allergy Immunol 107: 40-42.

4. A.D. Beaulieu, et al, (1995) Blood 86: 2789-2798.

5. H. Molina, et al, (1995) J Immunol 154: 5426-5435.

6. S Henchoz, J Y Bonnefoy, et al. (1994) Immunology 81(2): 285-290.

7. S. Mayall, Hamblin A.S., et al. (2001) J Comp Pathol 124(1): 83-87.

8. S Henchoz, J Y Bonnefoy, et al. (1996) Immunolgy 88: 35-39.