Human CD22 expression is restricted to normal Ig+ mature B cells and neoplastic B cells. CD22 is a transmembrane glycoprotein of 140 kd with a predicted adhesion molecule function.
Isotype: Murine IgG1
Immunogen: Human tonsil lymphocytes
Specificity: Antibody RFB4 recognizes the CD22 molecule of about 140 kd (1, 2, 3).
References:
1. D. Campana, et al, (1985) J Immunol 134: 1524-1530.
2. J.L. Li, et al, (1989) Cell Immunol 118: 85-99.
3. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 190-193.
4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 523-530.
5. D. Shan & O.W. Press, (1995) J Immunol 154: 4466-4475.
6. S. Behr & F. Schriever, (1995) J Exp Med 182: 1191-1199.
