Human CD100 is a transmembrane glycoprotein that belongs to the semaphorin gene family and is found on most hematopoietic cells except RBC, platelets and immature bone marrow cells. CD100 plays a key role in lymphocyte activation (2, 3). Interaction of CD100 with its ligand CD72 has implications in the mechanism of NK cell killing (4).
Isotype: Murine IgM
Immunogen: PHA stimulated human PBL
Specificity: Antibody 133-1C6 recognizes an extracellular epitope of the human CD100 molecule of about 150 kd.
References:
1.) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 534-539.
2.) K.T. Hall, et al, (1996) Proc Natl Acad Sci USA 93:11780-11785.
3.) A. Elhabazi, et al, (1997) J Biol Chem 272: 23515-23520.
4.) S. Mizrahi, O Mandelboim, et al.(2007) PLoS ONE 2(9):e818.
