Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4).
Isotype: Murine IgG2a
Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells
Specificity: Antibody JOVI-1 recognizes human C beta 1 TCR gene product and reacts with 50-75% of T cells in normal human blood (1). JOVI-1 does not bind to TCR C beta 2 (5).
Functional Application: Antibody JOVI-1 is mitogenic for T cells expressing TCR C beta 1.
References:
1. J.L. Viney, et al, (1992) Hybridoma 11: 701-713. PMID: 1284120
2. A. Weiss, (1993) Cell 73: 209-212.
3. M.M. Daris, (1995) Nature 375: 104.
4. S. Valitutti, et al, (1995) Nature 375: 148-151.
5. Paul M Maciocia, Martin A Pule, et al. (2017) Nature Medicine 23: 1416-1423.doi: 10.1038/nm.4444. Epub2017 Nov 13.PMID: 29131157
6. M Shi, P Horn, et al. (April 11, 2019) Clinical Cytometry https://doi.org/10.1002.cyto.b.21782
