Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4) and induces monocyte activation (5).

Isotype: Murine IgG1 kappa

Immunogen: Ectodomain of recombinant human 4-1BB fusion protein

Specificity: Antibody 4B4-1 recognizes an extracellular epiopte of the human CD137 molecule of about 35 kd on activated T cells (3).

Functional Application: Antibody 4B4-1 blocks binding of CD137 huIg to Raji cells. Immobilized mAb has been shown to induce TNF a production by monocytes(6) and IFNg production by NK cells(7).

References:

1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227.

2. H.J. Gruss, and S.K. Dower, (1995) Blood 85: 3378-3404.

3. B.A. Garni-Wagner, et al, (1996) Cellular Immunol 169: 91-98.

4. H. Schwarz, et al, (1996) Blood 87: 2839-2845.

5. J. Langstein, H. Schwartz, et al, (1998) J Immunol 160: 2488-2494.

6. G. Kienzle, J. von Kempis, (1999) Int Immunol 12(1): 73-82.

7. Baessler T, H R Salih, et al. (2009) 115(15): 3058-3069.